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Protein Fractionation

18 Product Families

Nanosep® and Nanosep MF Centrifugal Devices

Simple, Reliable Concentrating and Desalting of 50 to 500 µL Samples

 

  • Ensures rapid processing of samples 
  • Typical recoveries are > 90%
  • Available with low proteinbinding Omega™, Bio-Inert®, and GHP membranes
  • A wide range of MWCOs, color-coded for easy identification

 

23 Part numbers available

Microsep™ Advance Centrifugal Devices

Precise, Quick Recovery of Microliter Volumes

 

  • Achieve 50X concentration and > 90% recovery in just minutes
  • Deadstop feature prevents samples from spinning to dryness 
  • Versatile Omega™ membrane is available in a variety of MWCOs
  • Color-coded and laser etched for easy identification

 

14 Part numbers available

Macrosep® Advance Centrifugal Devices

Quickly Concentrates Up To 20 mL of Biological Sample

 

  • Rapidly concentrates 20 mL sample volumes to 0.5 mL
  • Provides high recoveries, typically > 90%
  • Low protein-binding Omega™ membrane and polypropylene housing minimize losses due to non-specific binding
  • Versatile Omega membrane is available in a variety of MWCOs

 

19 Part numbers available

Jumbosep™ Centrifugal Devices

Convenient and Reliable Concentration, Purification, and Diafiltration of 20 to 60 mL Biological Samples

 

  • Typically concentrates 60 mL sample volumes to 5 mL in 30 minutes
  • Provides high recoveries, typically > 90%
  • Low protein-binding Omega™ membrane and polysulfone housing minimize losses due to non-specific binding
  • Versatile Omega membrane is available in a variety of MWCOs, color-coded for easy identification

 

13 Part numbers available

Minimate™ Tangential Flow Filtration Capsules

Disposable TFF Device for Bioprocessing Applications Accelerates and Simplifies Processing of Up to 1 L

 

  • Efficient processing. Concentration and diafiltration (desalting or buffer exchange) processes can be performed on the same system with minimal user intervention.
  • Achieves high concentration factors in a single step due to the low holdup volume of the device. Process sample volumes up to 1 L or more and efficiently concentrate samples to as little as 5 mL.
  • Minimate TFF capsule includes all fittings and tubing to simplify installation into filtration setups. This versatile, self-contained device works with a variety of positive pressure laboratory pumps.
  • Cost-effective design for non-critical applications. The plastic construction of the Minimate TFF capsule and chemical compatibility of the Omega™ PES ultrafiltration membrane facilitate cleaning and reuse.

 

12 Part numbers available

Minimate™ Tangential Flow Filtration Systems

Minimate™ Streamlines Laboratory-Scale Concentration, Desalting, and Buffer Exchange Processes

 

  • Plug-n-play design. Plug in a Minimate TFF capsule, add sample, and turn on the pump to start processing. The Minimate TFF system includes all the hardware, tubing, and fittings needed to get your TFF process up and running quickly.
  • High concentration factors. The low system working volume achieved through the use of a conical bottom reservoir and compact design enables high concentration factors from up to 1 L or more of sample to be achieved. Concentrate your sample down to as little as 5 mL.
  • All wetted components are made from low protein binding, chemically resistant, biologically safe materials.
  • Minimal sample carryover. The system has a very low volume and interior fluid contact area. Fluid does not pass through and is not retained in the pump mechanism.

 

4 Part numbers available

AcroPrep™ Advance 96-Well Filter Plates for Ultrafiltration

Provides rapid, efficient separation of biomolecules

 

  • Omega™ membrane provides high recovery and typically results in > 90% recovery of target biomolecules
  • New well design results in faster, more uniform filtration rates across the plate with reduced hold-up volume for maximum sample recovery
  • Intrinsic plate and membrane properties prevent target molecules from binding to the plate

 

12 Part numbers available

AcroPrep™ Advance 96-Well Filter Plates for Protein Purification

Versatile Format for Multiple Purification Strategies

 

  • High performance Supor® membrane offers optimal support to retain chromatography sorbents while allowing smooth flow of buffers
  • Mustang® membrane is able to withstand high flow rates to render fast purification of biomolecules
  • New well design results in faster, more uniform filtration rates across the plate with reduced hold-up volume
  • New outlet tip geometry minimizes sample leakage and loss during incubation steps

 

13 Part numbers available

AcroPrep™ Advance 96-Well Filter Plates for Multiplexing

Superior Bead Recovery and Low Levels of False Positives Ensure Assay Reproducibility

 

  • Smooth well wall provides efficient bead recovery, ensuring reproducible results lot after lot
  • High performance membrane does not trap microspheres in the membrane matrix
  • In serological assays, Supor® membrane effectively removes IgG complexes, thus reducing nonspecific reactivity of the microspheres and reducing false positives
  • New well design results in faster, more uniform filtration rates across the plate with reduced hold-up volume 

 

8 Part numbers available

AcroPrep™ 96-well Filter Plates, 1 mL

Optimized for a Variety of Applications Requiring Larger Per Well Volume Processing

 

Discontinuation Notice

 

10 Part numbers available

AcroPrep™ Advance Filter Plates for Lysate Clearance

Prefilter Provides Efficient Clarification of Highly Particulated Samples

 

  • Integrated prefilter yields consistent filtration of samples with high levels of gross particulate
  • New well geometry results in faster, more uniform filtration rates across the plate with reduced hold-up volume
  • Innovative outlet tip geometry provides direct flow of samples into receiver plate without concerns of cross-contamination
  • Manufactured with biologically inert materials that allow clarification of most types of lysates without loss of target molecules

 

8 Part numbers available

AcroPrep™ Advance 96-Well Filter Plates for Solvent Filtration

Robust Chemical Resistance Provides Compatibility with Harsh Organics and Aqueous Solutions

  • Chemically resistant materials provide a stable platform to process samples in organic solvents
  • Inert materials of construction ensure complete recovery of samples and low non-specific binding
  • New well design results in faster, more uniform filtration rates across the plate and reduces hold-up volume
  • Innovative outlet tip geometry provides direct flow of samples into receiver plate without concerns of cross-contamination

 

16 Part numbers available

AcroPrep™ Advance 96-Well Filter Plates for Aqueous Filtration

Fast Processing with Efficient Removal of Particulates

 

  • New well geometry results in faster, more uniform filtration rates across the plate with reduced hold-up volume
  • New outlet tip geometry facilitates direct flow of samples into receiver plate without concerns of crosscontamination
  • Varied membrane and pore size selection offers efficient particulate removal
  • Manufactured in accordance with SBS guidelines, allowing plates to be run in manual, semi-automated and automated processes
  • Smooth top surface and textured window allow for easy labeling on the plates, as well as provide easy usage orientation through the A1 corner notch

 

16 Part numbers available

AcroPrep™ 384-well Filter Plates, 100 µL

Ideal for Use in High Volume, High Throughput Sample Prep Applications

 

  • Plates are constructed from chemically-resistant, biologically-inert polypropylene with a clear polystyrene lid.
  • Robotic-friendly design has single-piece construction, designed in accordance with the ANSI/SBS X-2004 standards. Plates are stackable with and without lids.
  • Eliminates crosstalk between wells. Membranes are individually sealed in each well with a proprietary sealing process and each well has a fluid director.
  • A serialized barcode label allows the use of automated tracking systems and identifies the membrane type.

 

1 Part numbers available

Omega™ Ultrafiltration Membrane Disc Filters

High Performance and Stability for Users of Conventional, Non-Disposable Stirred Cells

 

  • Polyethersulfone membrane provides higher flow rates and lower protein binding than competitive regenerated cellulose. This results in lower processing times and the highest possible recoveries.
  • Discs can be washed and reused.

 

14 Part numbers available

Ceramic HyperD™ F Ion Exchange Chromatography Sorbents (Q, DEAE, and CM)

Preparative Sorbents for the Purification of Biomolecules by Charge

 

  • High binding capacity. “Gel-in-a-shell” design delivers outstanding dynamic capacity and exceptional dimensional stability for unsurpassed productivity.
  • High flow rates. Proteins diffuse rapidly within the hydrogel, facilitating rapid uptake of product. This mechanism of mass transfer (known as “enhanced diffusion”) allows the sorbents to operate free of constraints.
  • Abundant ion exchange sites in the hydrogel are highly accessible to protein molecules.
  • Does not shrink or swell in response to changes in pH, ionic strength, or flow rate.

 

9 Part numbers available