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Minimize time to market and maximize all phases of development

Reduce filtration time, increase throughput, reduce the need for multiple filter changes and save in overall filtration costs. We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements, and exhibit superior performance compared to competitive filter devices. Many of these products are scalable. 

 

All too frequently, days or even weeks of cell culture work can be lost when bacterial, fungal, or yeast contaminants are unknowingly introduced. Unfortunately, the same nutrient media that is used to grow cell cultures is often ideal for promoting the growth of these contaminants, which can quickly ruin your cultures. While there is no substitute for aseptic technique, sterilization of liquids used during cell culture assures you that media and reagents are not a source of contaminants. Heat sterilization (autoclaving) is not an option for many liquids as autoclaving may destroy critical cell culture media components and biomolecules needed for normal cell growth. Filtration, therefore, is the method of choice for sterilizing cell culture media and additives. Filters capable of ambient sterilization are also useful for the general clarification and purification of cellular lysates as a means to enhance the recovery of target biomolecules. 

We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements. 

Whether you are preparing small volumes of reagents, individual bottles of buffers or media, or developing pharmaceutical processes, we have the products to optimize your sterile filtration applications. We can help you:

 

  • Reduce filtration time.
  • Increase throughput.
  • Reduce the need for multiple filter changes.
  • Save in overall filtration costs.

 

At Pall, quality and ease of use are engineered into every device. We manufacture our own membranes to ensure consistent performance from lot to lot. Examples of our stringent quality specifications include:

 

  • Sterilization by gamma irradiation – Products with Supor®, Fluorodyne® II, Versapor® membranes are presterilized by gamma irradiation to eliminate potential cytotoxic residuals associated with EtO sterilization. These presterilized devices are individually packaged for convenience.
  • Biological safety – Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>.
  • Non-pyrogenic – Products are tested for bacterial endotoxin using the Limulus Amoebocyte Lysate (LAL) test to ensure safety.
  • Low extractables – Products are optimized to reduce extractables, ensuring that unwanted materials are not introduced into filtered liquids.

 

We offer a range of different devices to match your filtration requirements, throughput and volumes:


Bottle-top Vacuum Filters

The sterile VacuCap bottle-top filter was engineered for media preparation for cell culture applications. VacuCap PF devices, designed with a built-in prefilter, increase throughput performance with serum-containing media or other viscous solutions.

 

 

Capsules

Capsules are suited for sterile filtration and prefiltration applications. Capsules are available with a variety of membranes to sterilize liquid reagents, remove particulate contamination and clarify solutions prior to further processing.

 

 

Membranes

Membranes are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements.

 

 

Syringe Filters

Sterile syringe filters rapidly filter small volume samples and are available with diameters of 13, 25, 32, or 37 mm.

 

Clarification and prefiltration

Filtration is an effective method to reduce particulate contamination in fluids. Filters may be used to clarify high particulate-load solutions such as reagents and buffers that are not required to be sterile.
Filtration is an effective method to reduce particulate contamination in fluids. Filters may be used to clarify high particulate-load solutions such as reagents and buffers that are not required to be sterile.
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Endotoxin removal

Endotoxin is a contaminant in plasmid preparations and bacterial protein expression that must be removed from research samples to avoid toxicity or interference in cell-based assays.
Endotoxin is a contaminant in plasmid preparations and bacterial protein expression that must be removed from research samples to avoid toxicity or interference in cell-based assays.
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Filter holders and membranes

Reuseable filter holders with separate membrane disc filters can provide the necessary flexibility for researchers to demonstrate proof-of-concept or conduct filterability trials before investing time and effort into more costly options.
Reuseable filter holders with separate membrane disc filters can provide the necessary flexibility for researchers to demonstrate proof-of-concept or conduct filterability trials before investing time and effort into more costly options.
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Mycoplasma reduction

Mycoplasmas are a common contaminant of cell cultures. Using our 0.1m membrane is your best assurance that mycoplasma will not be introduced into your cultures by serum or serum-containing media.
Mycoplasmas are a common contaminant of cell cultures. Using our 0.1m membrane is your best assurance that mycoplasma will not be introduced into your cultures by serum or serum-containing media.
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Sterile filtration

We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical, and sterilizing filtration requirements. 
We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical, and sterilizing filtration requirements. 
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Vacuum filtration

Vacuum filter units are popular lab essentials to filter media, serum, buffers and small-batch reagents. We offer products that eliminate contamination, risk of spills, and lost time by drawing fluid directly from mixing flask into the filter unit.
Vacuum filter units are popular lab essentials to filter media, serum, buffers and small-batch reagents. We offer products that eliminate contamination, risk of spills, and lost time by drawing fluid directly from mixing flask into the filter unit.
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